Causes, risk factors of rhabdomyosarcoma (part 2)

Published : 06 Oct 2021 08:04 PM | Updated : 07 Oct 2021 02:07 PM


It's not clear what causes rhabdomyosarcoma.

Doctors know that rhabdomyosarcoma begins when a cell develops changes in its DNA. A cell's DNA contains the instructions that tell a cell what to do. The changes tell the cell to multiply quickly and to go on living when healthy cells would normally die. The result is a mass (tumor) of abnormal cells that can invade and destroy healthy body tissue. The abnormal cells can break away and spread (metastasize) throughout the body.

Read More: Rhabdomyosarcoma, its symptoms (part 1)

Risk factors:

Factors that may increase the risk of rhabdomyosarcoma include:

Family history of cancer: The risk of rhabdomyosarcoma is higher in children with a blood relative, such as a parent or sibling, who has had cancer, particularly if that cancer occurred at a young age. But most children with rhabdomyosarcoma have no family history of cancer.

Genetic syndromes that increase the risk of cancer: In rare instances, rhabdomyosarcoma has been linked to genetic syndromes that are passed from parents to children, including neurofibromatosis 1, Noonan syndrome, Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome and Costello syndrome.

    Courtesy: Mayo Clinic

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