Following an enthralling and end-to-end encounter on matchday three of the 2021-22 Champions League, RB Leipzig and Paris Saint-Germain prepare to renew hostilities on Wednesday night.
Les Parisiens came out on top 3-2 in their first meeting with Jesse Marsch's side, thanks in no small part to inspired showings from Kylian Mbappe and Lionel Messi.
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PSG's standing at the top of the table is the only statistic that counts, and with seven points taken from their opening three Champions League clashes, Pochettino's men remain one point clear of Manchester City at the top of Group A. Les Parisiens have won three of their last four in all competitions heading into Wednesday's game - although all three of those successes came at the Parc des Princes - and Pochettino's side will be out to end a two-game winless and goalless run away from home at the Red Bull Arena.
PSG are reportedly preparing to make do without Lionel Messi for Wednesday's fixture, with the 34-year-old coming off at half time against Lille due to a combination of muscle discomfort and knee pain.
Pochettino is also without the services of Leandro Paredes, Marco Verratti and Sergio Ramos this week, but Kylian Mbappe is expected to return from an ear infection in time to lead the line alongside Neymar Jr.
Achraf Hakimi missed the Lille win through suspension but is set to displace Thilo Kehrer here, while Juan Bernat started for the first time in over a year on Friday, although Nuno Mendes should return for midweek.
Meanwhile, Leipzig have been boosted by the timely return of creative hub Dani Olmo ahead of this game, but he only came on for the final few minutes against Frankfurt and is highly unlikely to start just yet.
Defensive duo Lukas Klostermann and Marcel Halstenberg are both set to remain absent for the visit of PSG, while Brian Brobbey and Marcelo Saracchi also occupy spots in the infirmary.
With Olmo only expected to make the bench while Christopher Nkunku holds his place, Dominik Szoboszlai and Emil Forsberg are set to do battle for the final spot in the forward triumvirate.