Supportive treatments for HPP are directed toward specific symptoms and complications. Treatment may require a team of specialists. Pediatricians, orthopedic surgeons, pedodontists, pain management specialists and other healthcare professionals may be needed for comprehensive treatment.
Non-steroidal anti-inflammatory drugs (NSAIDs) may help bone and joint pain. NSAIDs require caution and monitoring for side effects (e.g. they can hurt the stomach and kidneys), especially in excess and if used too long. If craniosynostosis causes intracranial pressure, shunting or skull surgery may be necessary.
Vitamin B6 can help to control specific seizures in severely affected babies. Those with elevated levels of calcium in the blood (hypercalcemia) may need dietary calcium restriction, hydration, certain diuretics, and perhaps injections of calcitonin.
Regular dental care beginning early on is recommended. Physical and occupational therapy may be helpful.
Adults with recurring long bone fractures may need orthopedic “rodding” where a metal rod is inserted within the center cavity of a long bone to increase stability and strength. Special medical devices (foot orthotics) may help foot (metatarsal) fractures.
Patients should avoid bisphosphonates, a class of drugs used to treat other bone disorders such as osteoporosis. Bisphosphonates may worsen HPP or cause problems in individuals with undiagnosed HPP. Examples of bisphosphonate drugs are alendronate, ibandronate, pamidronate, risedronate and zolendronate.
Courtesy: Web MD