Treatment for hypophosphatasia (part 5)

Published : 05 May 2022 08:40 PM

Doctors use a drug called asfotase alfa (Strensiq) to treat HPP that starts in infancy or childhood. You get it as a shot under your skin. It replaces the ALP in your bones.

In addition to taking asfotase alta, you or your child will have a care team who will come up with other treatments and lifestyle changes to help with symptoms. These might include:

• Nonsteroidal anti-inflammatory drugs, or NSAIDs, like ibuprofen (Advil) or acetaminophen (Tylenol) for bone or joint pain

• Surgery on the skull or a shunt to ease pressure on the brain

• Vitamin B6, which can help control seizures in some cases

• Lowering calcium in your blood, by restricting your diet or getting injections of calcitonin, a hormone that regulates calcium levels

• Regular dental care

• Physical therapy

• Inserting metal rods into bones that frequently break

• Using a foot orthotic device or “boot”

• Avoiding bisphosphonate drugs, used to treat other bone disorders such as osteoporosis, since they can make HPP worse

There are also a few experimental treatments for HPP. One is a drug called teriparatide. It's sometimes used “off-label” to help heal small stress fractures in the feet of people with HPP, but doctors can't use it in children. Doctors can also use bone marrow and stem cell transplants to treat serious HPP.

    Courtesy: WebMD