A pivotal battle of the Brits takes place in World Cup 2022 Group B on Tuesday, as Wales take on familiar foes England at the Ahmad bin Ali Stadium.
The Three Lions will progress to the last 16 as group winners with all three points, while Wales - who lost 2-0 to Iran on Friday - must triumph and hope that other results go their way to stand a chance of making it through.
Plenty of Three Lions fans certainly enjoyed Wales' defeat on Friday lunchtime, but only several hours later, some of the England contingent in the crowd appeared to boo their own players off the field after an uneventful draw with the USA.
Christian Pulisic's effort which crashed against the crossbar represented the best chance of the game, as England lost their attacking acumen that saw them hit Iran for six on the opening day and missed the chance to wrap up a top-two finish with a game to spare.
Southgate questioned whether his players were in fact jeered off the pitch, but the Three Lions boss cannot deny that much more will be needed from his side on Tuesday, where a win would confirm England's place in the last 16 as Group B winners.
A draw would also be enough for the 1966 champions to progress - albeit while leading to a familiar sense of pessimism for the rest of the tournament - and a paltry record for England has seen them post just one win from their last eight in all tournaments.
Tuesday's game will mark the first time in history that the Three Lions have faced a fellow British nation in the World Cup, and there will certainly be no love lost between the two sides as they prepare to meet for the 104th time, with England winning the last six in a row.
Wales number one Hennessey will take his place on the suspension step for this one following his red card against Iran, opening the door for Danny Ward to start in between the sticks after a period of notable improvement at Leicester City.
Page did not pick up any new injury concerns in the loss to Iran, where Joe Allen was able to come off the bench following his hamstring injury, but the Swansea City man was largely at fault for Cheshmi's long-range effort with his poor clearance.
National team heroes Gareth Bale and Aaron Ramsey were practically anonymous in their matchday two showing, but Page is unlikely to consider dropping the duo for such an important fixture.
Daniel James and Brennan Johnson should be considered for places, though, as Kieffer Moore provides a much-needed physical presence in the final third.
As for England, Southgate could be working with a fully-fit squad for Tuesday's crunch clash after welcoming James Maddison back to training from a knee injury, and he is facing plenty of difficult selection dilemmas.
Kyle Walker's return to fitness could see the Manchester City man return to the right-hand side over Kieran Trippier, in spite of calls for Southgate to introduce Trent Alexander-Arnold into the fray.
Southgate was reluctant to bring on Phil Foden for Mason Mount in the number 10 role on Friday, but with Bukayo Saka enduring an off night against the USA, Foden could push for a start out wide.
Harry Kane is still waiting for his first non-penalty goal in England colours in 2022, but there is virtually no chance of the skipper losing his place in the side here.