According to the National Organization for Rare Diseases, the exact cause of this condition is unknown in about two-thirds of cases.
Age and gender are the greatest risk factors for the disease. According to the National Center for Biotechnology Information Trusted Source, it occurs most often between the ages of 40 and 60. However, it can develop at any age. The condition occurs twice as often in men as in women.
Specific conditions linked with retroperitoneal fibrosis can include:
• exposure to asbestos
• actinomycosis, which is a bacterial infection
• histoplasmosis, which is a fungal infection
• recent trauma of the abdomen or pelvis
• abdominal or pelvic tumors
The disorder can also be associated with:
• recent surgery on the abdomen or pelvis
• the use of cancer treatments involving external beam radiation
• certain medications to treat migraines and high blood pressure
Courtesy: Health Line